Semaglutide Impurities - Omizzur

Semaglutide is a glucagon-like peptide-1 (GLP-1) analog. This type of drug can delay gastric emptying and suppress appetite. It has obvious weight loss effects and has few side effects. It also has the effects of lowering blood sugar and improving metabolism in the body. 

Semaglutide increases insulin secretion and inhibits glucagon secretion. It can improve blood sugar levels in patients with type 2 diabetes and has a low risk of hypoglycemia.

Semaglutide may induce weight loss by reducing appetite and reducing food intake. Semaglutide has been approved by the U.S. FDA for use in combination with diet control and exercise to improve blood sugar control in adults with type 2 diabetes.

Peptide Synthesis and impurities

More than 90% of the peptide drugs currently on the market can be produced through chemical synthesis method. Peptide drugs are composed of amino acids. They are formed through the connection of amino acids step by step. For now chemical synthesis methods include liquid phase method, solid phase method, and combination of liquid phase and solid phase method.

The quality control level of peptide drugs is close to that of small molecule drugs, and their activity is close to that of protein drugs. They have good advantages in clinical application and production. 

To study the impurities in peptide, the first thing to think of is the amino acid deficiency. The efficiency of solid-phase synthesis cannot be 100% in every step. Sometimes amino acids are missing, some structures are modified, and even more the peptide chain itself may be broken.

There is also another kind of impurities: degradation. Some amino acids are prone to hydrolysis, oxidation, and polymerization reactions. Also if your team declare peptide products, ICHQ3 requires research and control on solvent residues, elemental impurities, and genotoxicity. The R&D team have to consider and study these possible problems and we have to say this is a very long and hard R&D process.

Peptide Characterization Report

Semaglutide Impurities 

Omizzur lab supply various peptide impurities, such as exenatide , semaglutide impurities etc for R&D use. Some products are in stock and some need custom-made.(delivery within 2-4 weeks). Please contact us to get the product details.

FAQs: What are the control strategies for peptide impurities?

The control medods for impurities mainly focus on 3 ways:

1. From the point of synthesis, suitable processes can reduce the generation of impurities and control them to a low level. We need to choose an ideal synthesis way.

2. From the point of separation and purification ways. Develop effective methods to remove or reduce impurity content. The purification of peptide drugs usually uses RP-HPLC . The core of chromatographic separation is to select the good filler.

3. Choose right storage method to reduce the degradation of impurities.

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