Substance P peptide is a neuropeptide widely distributed in fine nerve fibers. When the nerve is stimulated, substance P can be released at the central and peripheral terminals, binding with NK1 receptors to exert physiological effects. Substance P may be an important substance for neural information transmission. Recent studies have found that substance P is related to human learning and memory abilities.

Substance P & Neuropeptide

In medicine, substance P refers to a neuropeptide widely distributed within nerve fibers, released from central and peripheral peripheral nerves.

After the body's nerves are stimulated, substance P is released in large quantities and binds to NK1 receptors to exert physiological effects. Clinical studies have shown that this substance is related to pain transmission, with its C-terminus involved in pain transmission, while its N-terminus can be flipped by naloxone and produce analgesic effects. At the same time, this substance can also directly or indirectly promote the release of substances such as glutamate and participate in pain transmission.

If tooth pain, closed or developmental trauma causes pain, visceral organ pain, etc., the nervous system can release substance P and transmit pain to the brain. At the same time, this substance can also have a mild analgesic effect by promoting the release of enkephalin. Therefore, it is clinically believed that substance P is an important substance for the transmission of information in the nervous system. It plays a role in sensation, movement, and emotional regulation.

In addition, studies have pointed out that this substance is related to the pathogenesis of mental and psychological disorders, such as anxiety, depression, schizophrenia, etc. If symptoms such as physical pain and emotional abnormalities occur, it is important to seek medical examination as soon as possible, clarify the specific cause, and choose a suitable treatment plan accordingly.

Substance P peptide

Property: A neuropeptide widely distributed within fine nerve fibers.

Type: Belongs to the tachykinin family

Distribution: Widely distributed in the brain, it is more abundant in the brain regions responsible for regulating emotions (amygdala, periaqueductal gray matter, and hypothalamus, etc.), and has high expression in the cell bodies and nerve fibers of primary sensory neurons.

Substance P - reference for concentration of preparation solution

**Please select the appropriate solvent to prepare the reserve solution based on the solubility of the product in different solvents. Once the solution is prepared, please separate and store it to avoid product failure caused by repeated freeze-thaw cycles.

On the synthesis of Substance P Peptide in Omizzur Lab

Omizzur Lab is a biological company specializing in custom peptide synthesis. Substance P peptide is currently in stock supply. And Omizzur Lab accept various customized peptide synthesis services. Please contact the Omizzur team for details.

Substance P CAS 33507-63-0 | Omizzur

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Storage

When peptides are received, please make sure they are kept in a cool, dark place. For best storage, store them under fridge at 4°C or colder, away from bright light. Solid peptides are stable at room temperature for a few weeks. For long-term storage, -20-80°C is best.

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