Melittin CAS 20449-79-0 | Melittin for Sale

Cancer Remains One of The Most Terrifying Diseases that Threaten Human Life Safety

At present, the treatment methods for cancer have made some achievements in some early and middle stage cancers, and the curative effect for cancer with metastasis or recurrence is not good. In a wide range of studies, bee venom has shown anti-cancer effects in a variety of malignant tumors, and bee venom peptide is the main active component and anti-tumor component of bee venom

What is Melittin?

Melittin is the most important peptide in bee venom, which consists of 26 amino acid residues. It has a wide range of pharmacological effects and high biological activities. It can not only be used to treat arthritis, rheumatism, pain, neurodegeneration, skin diseases and other diseases, but also has good anti-tumor activity. It shows therapeutic effect on more than 60 different types of human cancer cells. It can not only directly kill tumor cells by destroying the phospholipid bilayer of cell membrane, but also inhibit tumor angiogenesis, induce tumor cell apoptosis, participate in immune regulation, inhibit tumor cell proliferation, invasion The ability of migration interferes with the biological behavior of tumor tissue and plays an anti-tumor role.

Melittin has a variety of targets, complex mechanisms, and is not easy to produce drug resistance. It shows different action pathways when it plays a role in different types of tumor cells, and shows good synergistic effects with radiotherapy, chemotherapy and targeted therapy. It is expected to alleviate the pressure caused by chemotherapy and targeted therapy drug resistance and radiotherapy resistance. Melittin can also participate in immune regulation and activate the body's immune response to help fight tumors. The application of melittin has been greatly improved by the research on the molecular structure modification or modification of melittin, the mode and route of administration, and the delivery system.

5 Anti-tumor Mechanisms of Melittin:

1. Directly kill tumor cells

Melittin kills tumor cells mainly by disrupting the integrity of the phospholipid bilayer of the cell membrane, thereby altering the permeability of the cell membrane and causing cell damage.

2. Inhibiting tumor angiogenesis

Tumor angiogenesis refers to the generation of new blood vessels during the growth process of tumors. Unlike normal blood vessels, vascular endothelial growth factor (VEGF) is considered an effective target for anti-tumor therapy. Research has found that melittin can significantly inhibit angiogenesis in human highly metastatic liver cancer cells, thereby affecting the proliferation and invasion of tumor cells.

3. Interference with tumor biological behavior

Malignant tumors exhibit biological behaviors such as infinite growth, diffusion, and metastasis. Melittin can interfere with these biological behaviors of tumor tissue by inhibiting the proliferation, invasion, and metastasis of tumor cells.

4. Inducing tumor cell apoptosis

Cell apoptosis is a programmed death process mediated by endogenous and exogenous signaling pathways triggered by various factors such as cell stress, DNA damage, and immune monitoring. The development of therapeutic methods that promote effective clearance of tumor cells by inducing tumor cell apoptosis has been a pillar and goal of clinical oncology in the past 30 years. Research has demonstrated the role of melittin in inducing apoptosis in human esophageal cancer cells.

5. Immunomodulatory effects

Tumor associated macrophages (TAMs) can be divided into two different phenotypes: Mlh and M2, and M2 type TAMs can be released

Chemokines, angiogenic factors, and various extracellular matrix components have tumor promoting effects such as promoting angiogenesis and immunosuppression, and may cause tumor cells to resist chemotherapy.

In addition, chemotherapy, as one of the important means of tumor treatment, has limited therapeutic effects due to its side effects and drug resistance. Melittin not only has synergistic effects with chemotherapy drugs, but also increases the sensitivity of tumor cells to chemotherapy and reduces the side effects of chemotherapy.

Melittin for Sale

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It is valid for at least one year if stored at -20 ℃ or lower. Since each freezing and thawing of polypeptide will cause partial inactivation, after the storage solution with corresponding concentration is prepared for the first time (please prepare the storage solution according to the information in the column of reconstitution in the product introduction), it must be frozen at -20 ℃ or lower after sub packaging to avoid repeated freezing and thawing.

Shipping: By air or FedEx Express, delivery time: 5-10 days

Matters Needing Attention:

This product is freeze-dried powder. Since a small amount of polypeptide is deposited in the tube during the freeze-drying process, forming a very thin or invisible polypeptide layer, before opening the tube cover, we recommend centrifuging about 8000-12000g in a centrifuge for 10-30 seconds to make the peptide attached to the tube cover or tube wall gather at the bottom of the tube.

This product is only used for scientific research by professionals, and shall not be used for clinical diagnosis or treatment, food or drugs, or stored in ordinary houses.

For your safety and health, please wear lab clothes and disposable gloves.

Quality Assurance

1. For all batches of products, we will keep samples after one year of validity. When customers raise objections, we can make a quick response.

2. For the products purchased by customers, an original of our inspection report will be attached with the goods, including batch number, date, etc.

3. If you have any problems in use, please feel free to contact us and we will help you solve them as soon as possible.

Order Guidance

1. After you confirm the purchase, please inform our sales staff of your detailed requirements, including product name, quantity, packaging requirements, etc., as well as your receiving address, company name and contact information; Then our sales staff will make an order for you.  

2. Omizzur is a professional peptide manufacturer, there will be a huge discounts for bulk purchase. Distributors are welcomed.