Pyruvic acid Manufacturer CAS 127-17-3

Overview of Pyruvic acid

Pyruvic acid, also known as 2-oxopropionic acid, α-ketopropionic acid, or acetylformal acid, is one of the most important organic acids. It has a wide range of applications in fields such as pharmaceuticals, food, chemicals, agricultural chemicals, and scientific research.

Pyruvic acid a very important role in bioenergy metabolism. The derivative products of pyruvate series, including methyl pyruvate, ethyl pyruvate, creatine pyruvate, calcium pyruvate, potassium pyruvate, sodium pyruvate, magnesium pyruvate, etc., are widely used in the fields of medicine, chemical industry, etc. They are also raw materials for various chemical products, pesticides, etc.

The uses of Pyruvic acid and its derivatives mainly include the following aspects:

(1) Pharmaceutical industry: used for enzymatic synthesis of L-tryptophan, L-tyrosine, L-dopamine; Synthesize L-cysteine, L-leucine, vitamins B6 and B12, etc; Synthetic angiotensin II resistance, series of enzyme protein inhibitors, sedatives, Xinkefen, isoniazid calcium pyruvate, 2-phenylquinoline-4-carboxylic acid, Enbopyruvate, phosphoenolpyruvate, 4-methylazolic acid, thiamine, etc. In addition, calcium pyruvate can also be used as a weight loss health medication. 

(2) Daily chemical industry: Ethyl Pyruvic acid can inhibit the formation of tyrosinase in the epidermis and whiten the skin; Can be used as a preservative and antioxidant in cosmetics; Used as an air freshener. 

(3) Agricultural chemicals: Pyruvic acid is the starting material for synthesizing various pesticides such as ethylene based polymers, hydrogenated atopic acid, and grain protectants. 

(4) Food/feed industry: In GB2760-1996, pyruvic acid is designated as an acidic additive and has anti-corrosion and preservation functions. 

(5) Cell culture and biochemical research: forming antioxidants with lactic acid to reduce cell damage; Sodium pyruvate can serve as an alternative carbon source in cell culture and is an important substrate for animal cell culture. Used for the identification of primary and secondary alcohols, determination of transaminases, and as a chromogenic agent for aliphatic amines. 

Production of pyruvic acid

The industrial production methods of pyruvate mainly include chemical synthesis, enzyme conversion, and microbial fermentation. The chemical synthesis method oxidizes tartaric acid (or lactic acid ester) to acetone ester in the liquid or gas phase, and then hydrolyzes it to pyruvate. However, this method is heavily polluting, costly, and lacks competitiveness.

Some other chemical conversion methods, such as hydroxypropanol method and lactic acid oxidation method, all have problems such as insufficient raw materials or lack of industrial feasibility in terms of cost. Enzyme conversion method is the use of enzyme systems in microbial cells to dehydrogenate and oxidize lactic acid to pyruvate. This method has a high conversion rate but high substrate cost.

Microbial Fermentation of Pyruvic acid- IndustrialLarge-scale Production

Microbial fermentation method uses low-cost glucose as a substrate to produce pyruvate through fermentation. At present, the microorganisms that can produce pyruvate through fermentation mainly include yeast, basidiomycetes, actinomycetes, and bacteria. By constructing a new type of E. coli engineering strain, high conversion fermentation of pyruvate production using glucose as raw material has been achieved. This method is green, environmentally friendly, sustainable, and has good competitiveness, with good industrial application prospects. 

Storage: Store at 2°C - 8°C, protect from light.

Shipping: by air or sea, sample by FedEx/DHL.

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