Starting in 2020, Omizzur peptide platform began to provide custom peptides and impurities, protected amino acids & peptide reagent to 1,000+ customers around the world. We offer a variety of options for synthesis scales, purity levels, modifications, and salt forms. Our goal is to provide peptide products for your drug discovery research quickly and with high quality.

Equipped with a technical talent team and internationally advanced equipment, Omizzur Ltd provides a full range of high-quality customized peptide services, including rapid peptide synthesis, standard chemical peptide synthesis, peptide modification, peptide library and kinds of protected amino acids and reagents to meet biological and drug discovery research growing demand for peptides.

• Optional specifications: milligram (mg) level to kilogram (kg) level.

• Purity range: crude peptide, desalted, 70% to 98%.

• Extensive modification: 300+ different modifications including amidation, acetylation, methylation, phosphorylation, labeling and conjugation are available.

• Synthesis technology: solid phase synthesis, liquid phase synthesis, microwave and connection technology.

• Free consultation: The professional Omizzur technical team will answer your pre-sales and after-sales technical questions about peptide customization.

Omizzur's advantageous products mainly focus on:

1. Custom peptide and impurities: Semaglutide, Exenatide, salmon calcitonin etc.,

2. Fmoc/boc-amino acids, reagents: Fmoc-Arg(Pbf)-OH, Fmoc-OSu, PyAOP etc.,

Click here to see Omizzur Leading Products at 2024: Omizzur Product Catalogue

Fast Peptide Synthesis Quote Online:

 Quote & Order:

 1. Click to send inqauiry online:  Make Inquiry Now 

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  * Please mail us your product name and quantity needed, Omizzur will get back to you within 1 hour.

FAQs 1: What are Peptide Products?

Peptides are compounds formed by connecting amino acids with peptide bonds. They have a variety of biological functions, such as anti-thrombosis, anti-hypertensive, antibacterial, antiviral, anticancer, antioxidant, immune regulation, cholesterol-lowering, etc., and are now widely used. It is used in fields such as functional analysis, antibody research, vaccine development and drug research and development.

2.Basic principles of peptide synthesis:

Peptide synthesis typically uses peptide solid-phase synthesis, a step-by-step chemical reaction process that builds polypeptide chains through repeated additions of individual amino acids. During this process, the carboxyl group of each amino acid reacts with the amino group of the previous amino acid to form a peptide bond, releasing water molecules.

If you need customized peptides, we need to confirm your product sequence, required quantity, and purity requirements. We will conduct professional evaluation and quotation.

3. Why customize peptides?

Custom peptide synthesis has a wide range of applications in areas such as drug development, immunology research, biotechnology, and materials science. By customizing peptides with specific sequences, scientists can study protein function, structure, interactions, and their role in disease. In addition, customized peptides can also be used in the development of vaccines, drugs, or biomaterials.

4. How to customize peptide synthesis?

Customized peptide synthesis usually includes the following steps:

  - Design: First determine the desired peptide sequence and its purity, length, and modifications (such as fluorescent labeling, biotinylation, etc.).

  - Synthesis: Choose an appropriate synthesis strategy (e.g. solid phase synthesis or liquid phase synthesis) and add amino acids step by step under controlled conditions.

  - Purification: After the synthesis is completed, high-performance liquid chromatography (HPLC) and other techniques are used to purify the peptide to ensure that its purity meets the requirements.

  - Verification: Verify the quality and sequence correctness of the peptide through mass spectrometry and other methods.

5. Which salt form should I choose for my peptide?

When developing your peptide, you will need to select a salt form that will support your later clinical studies or other intended uses. Most peptides will form salts if there are free amino groups (such as Arg, Lys and His) on the N-terminus of the peptide sequence or on its side chain.

Many of the peptides used in early development were in the form of trifluoroacetic acid (TFA) salts, which were formed by exposure to a TFA/H2O buffer system during reversed-phase high-performance liquid chromatography (HPLC) purification. In solid-phase peptide synthesis (SPPS), peptides may also be exposed to TFA during cleavage from the resin support. The TFA salt can be converted to another salt form (e.g. acetate or hydrochloride) by ion exchange in a subsequent step.

Acetate is the most common counterion choice and is preferred over HCl and TFA salts in late-stage development due to the fact that the acetate form of the peptide generally yields better lyophilized solids than is possible with TFA salts in contrast to some unmanageable "fluffy" peptides. At the same time, peptides in TFA salt form may also cause adverse immune responses during clinical trials, and you may consider starting with the acetate form to avoid changes after your product is developed.

1. Trifluoroacetate (TFA): This is a salt often used in peptide products. However, due to the high biological toxicity of trifluoroacetic acid, some experiments need to avoid using this type of salt. Such as cell experiments.

2. Acetate (AC): The biological toxicity of acetic acid is much smaller than that of trifluoroacetic acid, so most of the salts used in pharmaceutical peptides and cosmetic peptides are acetate, but the acetate in some products is unstable, so Sequence stability also needs to be considered.

3. Hydrochloride (HCL): This type of salt is rarely selected. Only some sequences use hydrochloride for special purposes.

4. Ammonium salt (NH4+): This type of salt will seriously affect the solubility and stability of the product, and must be selected according to the sequence.

5. Sodium salt (NA+): Generally it will also affect the stability and solubility of the product.

6. Pamoic acid: This type of salt is often used in polypeptide drugs to make sustained-release agents.

7. Citrate (Citric Acid): This type of salt has relatively low physiological toxicity, but the preparation process is very complicated, so the production process needs to be developed based on the sequence alone.