Since the 1980s, antimicrobial peptides (AMPs), also known as antimicrobial peptides, have attracted much attention because of their inhibitory effect on infectious microorganisms and are considered to be the most promising alternatives to antibiotics. With the in-depth study of antimicrobial peptides, their antiviral effects are constantly being excavated, which can prevent the process of viral infection through various mechanisms, such as herpes virus, hepatitis virus, human immunodeficiency virus (HIV), etc. all have an envelope structure , antimicrobial peptides affect viral reproduction, assembly, and release by binding to the viral surface envelope and perforating it.

According to the current difficulties of HBV infection and treatment, combined with the antiviral effects of antibacterial peptides that have been discovered, scholars have simulated the structural characteristics of natural antibacterial peptides, designed and synthesized a series of chemically synthesized peptides, and tested the anti-HBV effects of chemically synthesized peptides in vitro. It not only proves the feasibility and effectiveness of peptides against HBV, but also provides new ideas for the search for new HBV clinical drugs in the future.

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