Immunoactive peptides are a class of polypeptides that can enhance immunity and play an immunomodulatory role. Divided into natural, chemically synthesized and recombinant immunoactive peptides. The most studied natural immune active peptides are endogenous opioid peptide (EOP) and muramyl dipeptide (MDP).

The first class of peptides discovered in the central nervous system is opioid peptides, which belong to the class of neurohormones, and have been deeply researched into three categories: endorphins, enkephalins and dynorphins. The research results show that opioid peptides can participate in almost all aspects of the immune response, mainly in the endocrine and paracrine ways. At the same time, the activated immune cells can also synthesize opioid peptides again and release opioid peptides. Chemically synthesized peptides are a class of immunologically active peptides that can be prepared by in vitro proteolysis and protein hydrolysis or in vivo digestion. The most studied are milk-derived immunomodulatory peptides, marine extract peptides and placental immunomodulatory peptides.

Immunoactive peptide synthesis method:

Divided into solid phase method and liquid phase method. The liquid phase method is not suitable for the low solubility of reaction intermediates, and this method is mainly suitable for the synthesis of small peptides. In order to make up for where the liquid phase method is not applicable, the solid phase method has been developed. Polypeptide solid-phase synthesis is one of the most important research methods in the field of peptide and protein research at present, but this method also has certain limitations, which is limited to the synthesis of 40-200 amino acids.