Marine natural bioactive substances are the focus of modern biological research, and natural marine bioactive peptides are an important part of marine bioactive substances. Because the living environment of marine organisms is very different from that of terrestrial organisms, marine organisms have diversity, complexity and particularity, so the marine natural products derived from them are different from that of terrestrial natural products, which provides a rich material source for the search for new natural active substances. Bioactive peptides are peptides with special physiological activities. According to their sources, they can be divided into natural active peptides, protease hydrolyzed active peptides and chemically synthesized active peptides. In 1902, Bayliss and Starling of the University of London School of medicine first discovered the active polypeptide substance secretin. Since then, the research on polypeptides has gradually deepened, and tens of thousands of bioactive polypeptides have been discovered, among which nearly 100 polypeptides are produced as drugs. It has made great contribution to human resistance to diseases.

Natural marine active peptides

In recent years, many scientists have devoted themselves to the isolation of bioactive peptides from deep-sea bacteria, fungi, microalgae and marine molluscs, and have made great achievements in anti-tumor, anti-virus, immune regulation and so on. Although a large number of active peptides have been isolated from marine organisms, only a few of them can be developed and enter the market as drugs, and a considerable number of new compounds are used as lead compounds to provide clues for the research of new drugs; There are also some marine active polypeptides with little content in organisms, so after their physiological activity and structure are determined, the total synthesis and solid-phase synthesis technology are used to realize their industrial production.

In recent years, many scientists have made great progress in isolating bioactive peptides from deep-sea bacteria, fungi, microalgae and marine molluscs. These peptides are complex and diverse in structure, and participate in important biological activities

Life activity, with important basic research and clinical application value, is a very important source of new drugs.

1. Antimicrobial peptides some organisms produce a large number of cationic peptides with antimicrobial activity when stimulated by the external environment, so that they have natural immunity. At present, more than 100 kinds of antimicrobial peptides have been isolated, some of them are antimicrobial peptides

Peptide not only has strong bactericidal ability, but also can kill tumor cells. The discovery of these marine polypeptides provides clues for finding new antibiotics.