Teriparatide acetate CAS 99294-94-7

Osteoporosis is a systemic bone disease characterized by decreased bone mass and increased brittleness caused by the damage of bone microstructure. With the aging of the world population, it has become a serious social problem. According to pharmacology, osteoporosis drugs are mainly bone resorption inhibitors and bone formation promoters.

Teriparatide is a recombinant human parathyroid hormone (PTH) analogue (rhpth[1-34]) composed of 34 amino acids. It can regulate bone metabolism, renal tubular reabsorption of calcium and phosphorus, and intestinal calcium absorption. It is suitable for the treatment of osteoporosis with high fracture risk in postmenopausal women and osteoporosis with high fracture risk induced by continuous glucocorticoid treatment

The amino acid sequence of teriparatide is composed of 34 conventional amino acids, with a large number of amino acids, forming a certain secondary structure. Fragment condensation strategy is adopted to reduce the preparation difficulty. The tripathide was divided into 4 fragments, 4 using Royal resin as the solid-phase carrier, and the other fragments using 2-clctc-resin as the solid-phase carrier to synthesize the peptide resin. After 1 ~ 3 peptide resins were cleaved to the fully protected peptide, they were successively condensed to the peptide resin according to the peptide sequence, Finally, after TFA cleavage, side chain protection group removal and purification, teriparatide (scheme1) was obtained. The purity was more than 99% and the overall yield was 33%. Its structure was confirmed by MS (ESI). This method shortens the synthesis cycle, simplifies the operation of solid-liquid phase synthesis, avoids the use of unconventional amino acids, and has a high yield, which is convenient for industrial production.

Omizzur also provides custom peptide synthesis of a series of teriparatide impurities.

Name: Teriparatide acetate

Synonym:  Parathar acetate; hPTH 1-34 (acetate salt)

CAS:99294-94-7 (acetate)

Sequences:H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2, acetate

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Molecular formula：C183H295N55O53S2

Molecular weight::4117.8

Solubility: Soluble in DMSO, not in water

Teriparatide HPLC

It is valid for at least one year if stored at -20 ℃ or lower. Since each freezing and thawing of polypeptide will cause partial inactivation, after the storage solution with corresponding concentration is prepared for the first time (please prepare the storage solution according to the information in the column of reconstitution in the product introduction), it must be frozen at -20 ℃ or lower after sub packaging to avoid repeated freezing and thawing.

Shipping: By air or FedEx Express, delivery time: 5-10 days

Matters needing attention:

This product is freeze-dried powder. Since a small amount of polypeptide is deposited in the tube during the freeze-drying process, forming a very thin or invisible polypeptide layer, before opening the tube cover, we recommend centrifuging about 8000-12000g in a centrifuge for 10-30 seconds to make the polypeptide attached to the tube cover or tube wall gather at the bottom of the tube.

This product is only used for scientific research by professionals, and shall not be used for clinical diagnosis or treatment, food or drugs, or stored in ordinary houses.

For your safety and health, please wear lab clothes and disposable gloves.

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