This article is a popular science article about custom peptide synthesis price list. This content covers the scope of custom peptide services, the price of custom peptides, the quality control of custom peptide synthesis, the market of custom peptides, the Top 5 professional companies for custom peptide synthesis, etc. The article is about 1,700 words, you can save it for reading next time.

What is Custom Peptide Synthesis?

Simply put, it means supplying high-quality peptide products according to the customer's customized requirements. Most of these peptide products require custom synthesis, and the delivery time is generally 2-4 weeks depending on the difficulty of the synthesis.

Key Points You Will Need to Confirm for Custom Peptide Synthesis:

What Range of Peptide Synthesis Services are Available?

1. Research-level Custom Peptide Synthesis: 

including peptide synthesis from literature, peptide sequence synthesis provided by pharmaceutical companies/peptide laboratories, peptide impurity synthesis, peptide modification, peptide library synthesis,

Example:

Amyloid peptide, RGD peptide, Melittin, semaglutide impurities synthesis, Truncation peptide library synthesis;

2. API Peptides / Cosmetic Peptides

This type of peptide is a conventional peptide variety: most of them can be provided in stock, and there are complete test reports for this batch. Support fast delivery & global transportation

Example: Semaglutide, Tirzepatide, Exenatide, L-Carnosine, GHK-CU;

3. Peptide Raw Materials

The raw materials of peptides include various protected amino acids, resins, peptide synthesis reagents, etc., including:

Fmoc amino acids, Boc amino acids, Cbz-amino acids, Unnatural amino acids, Wang resins, Fmoc amino acids attached wang resin, Fmoc-OSu;

Regarding the Modification of Peptides, What Does it Include?

1. Conventional modification of C/N terminus: 

C-terminal modification: including amidation, sulfation, etc. These modifications can change the charge state of the peptide, thereby affecting its interaction with other molecules.

N-terminal modification: such as acetylation, fatty acidization, etc. These modifications can enhance the stability of the peptide, prevent it from being degraded, and also change its biological activity.

2. Regulate protein/peptide activity and stability

Such modifications include: glycosylation, methylation, phosphorylation, peptide cyclization, PEG modification, peptide-protein coupling(KLH,BSA,OVA), etc.

3. Peptide labeling: 

Biotin labeling, fluorescent labeling (such as 5(6)-FAM, FITC, CY5), isotope labeling (C13, N15), fatty acid modification (Pal, Myr), rhodamine labeling.

4. Others:

D-amino acids, amino acid derivatives, disulfide bond modifications; These different modifications will affect the price of the final custom peptide synthesis.

Custom Peptide Synthesis Price List for References:

*** This list is only for reference for small quantities of simple linear peptides. When the order quantity is greater than 100 mg, discount will be available. Please consult our customer service staff.

Suggestions on the Storage and Solubility of Peptides

Storage of Peptides:

Freeze-dried peptide products can be placed at room temperature and should generally be placed in a desiccator. For peptides containing amino acids such as Cys, Met and TrP in the sequence, they are easily oxidized in the air. Before sealing the bottle, inert gas should be slowly injected to reduce oxidation.

Unless otherwise specified, all peptides in the catalog are generally packaged as vials of freeze-dried powder. We recommend dissolving the peptide in sterile distilled water or deionized water first. If the peptide is to be stored for a long time, it is best to freeze-dry it. The freeze-dried powder can be stored for more than a few years at -20° or lower.

Solubility of Peptides:

For some peptides that are difficult to dissolve in double distilled water or buffer, dilute acetic acid (30%-50%) or dilute ammonia (about 30%) is often used to dissolve alkaline (containing Arg, Lys, His) or acidic (containing Asp, Glu) peptides. Peptides that are insoluble by these methods need to be dissolved with a small amount of DMF or DMSO, and then an appropriate amount of buffer is added. These solvents may have side effects on some experiments, so be careful during the experiment.

Note: The presence of these amino acids in the peptide chain: Ala, Cys, Ile, Leu, Met, Phe, Gln, Asn and Val will increase the difficulty of peptide dissolution.

Storage of Peptide Solution

The solution peptide is far more unstable than the lyophilized form. The solution should be adjusted to (pH 5-7) and stored at -20°C. Avoid repeated freezing and thawing of samples (peptide solutions with Met, Cgs or Try residues are more susceptible to oxidation and have a limited lifespan. To prevent damage from repeated freezing and thawing, it is recommended to dissolve a certain amount of peptides and store the remaining peptides in a dry powder state)

Other solution peptides are best stored in small samples. If a sample is not used up after thawing, it is best to throw it away, because bacterial degradation will cause trouble for the solution peptide in the experiment. To overcome this, the peptide should be dissolved in sterile water, or the peptide solution should be filtered with a 0.2μ M filter membrane. (Note: If the sample is not completely dissolved, the sample will be lost, and a small amount [approximately 1 mg] should be taken).

What are the Current Research Areas of Peptides?

Peptides have a very important and irreplaceable regulatory effect on the human body, which involves almost all physiological activities of the human body. Such as: nerves, digestion, absorption, metabolism, circulation, growth, reproduction, endocrine, etc.

At present, many studies on peptides have been used in the development of medicine and health foods. The insulin we are familiar with is a peptide, and oxytocin and vasopressin are both peptide hormones. In a high-rhythm, highly tense society, the number of people with abnormal sleep is increasing, and hypnotic peptides will be the best choice because they have no side effects. Other effective drugs such as those that can treat diabetes, gastric ulcers, pancreatitis, dwarfism, and gallbladder contraction are all peptides.

For the human immune system, peptides are more important and direct, such as mannan peptides, thymic peptides, albumin peptides, placental peptides, etc., which can quickly activate macrophages and T cells, thereby improving the level of human cellular immunity and preventing infections caused by coronaviruses such as SARS.

Can New Synthesis Processes Reduce Synthesis Costs?

The answer is yes. With the continuous advancement of science and technology, peptide synthesis technology is also constantly developing, and new synthesis processes are constantly emerging, which provides the possibility of reducing the cost of synthetic peptides.

Efficient synthesis methods: New efficient synthesis methods, such as solid-phase peptide synthesis and liquid-phase peptide synthesis, can significantly improve the synthesis efficiency of peptides, reduce synthesis time and the amount of raw materials required, thereby reducing production costs.

Improvement of catalysts and reagents: The development of new catalysts and reagents makes peptide synthesis reactions more efficient and rapid, while also reducing waste generation, which is beneficial to environmental protection and cost control.

Automated and intelligent production: With the continuous development of industrial automation, the synthesis of peptides can also be automated and intelligently produced. This can not only improve production efficiency and reduce labor costs, but also reduce human errors and improve product quality.

Optimization of raw material costs: By optimizing raw material selection and using lower-priced and higher-purity raw materials, the cost of peptide synthesis can also be effectively reduced.

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