Pentapeptide-18 | Leuphasyl | 64963-01-5 | Omizzur

Pentapeptide-18 is a kind of synthetic peptide, which can be used for resist muscle contraction, facial expression lines, wrinkle and smooth skin.  It belongs to anti-aging and eye care products. Pentapeptide-18 is a short peptide that has been studied for its ability to reduce signs of aging, including minimizing the appearance of expression lines and visibly reducing wrinkle depth. It is often referred to in the scientific literature as a "neuropeptide," where "neuro" refers to nerves. Pentapeptide-18 has also gained attention in studies for its ability to hydrate skin and improve firmness.

The "penta" portion of pentapeptide-18 refers to its five amino acid portion. It helps visibly lighten dark spots and other forms of uneven tone. More independent research is needed to verify these findings, but it does look promising. A study (funded by the Colgate-Palmolive Company and PCA SKIN) showed that when the amino acid D-tyrosine was added to the formulation of pentapeptide-18, it helped to visibly lighten dark spots and other forms of uneven skin tone. The effective level of this peptide is 0.025% to 10%, depending on the formulation goals and the amount of peptide present in solution or powder form, which varies between suppliers.

Gravity wrinkles are mainly due to subcutaneous tissue fat, muscle and bone atrophy, skin aging, coupled with the long-term effect of gravity and gravity. However, some people according to the causes of wrinkles are divided into physiological wrinkles, pathological wrinkles and light wrinkles and aging wrinkles, and so on. 

Related Pentapeptide-18 Research Tests

Pentapeptide-18 targets expression wrinkles that appear due to facial movements. It works similarly to the older, better known Argireline (Acetyl Hexapeptide-8). They have similar effects, but work in different ways. When the two are mixed and act synergistically (the brand name is Argirelox), it hinders the muscle contraction process in two different stages, so that the anti-wrinkle can achieve a more comprehensive effect. In vivo tests show that after 28 days, only 5% leupiferin can reduce wrinkles by 11%, and 5% leupiferin + 5% ajirelin can reduce wrinkles by an average of 25%. up to 47%.

Pentapeptide-18 / leucine is a new anti wrinkle peptide. In vitro simulation of natural enkephalin mechanism: outside nerve cells, it binds to enkephalin receptor, ligand binds to receptor, conformation changes start cascade reaction in nerve cells, leading to the decrease of excitability: nerve cell activity is "down regulated" and acetylcholine release is adjusted, muscle contraction will slow down, thus reducing wrinkles.

It is often cited in studies along with another neuropeptide called acetyl hexapeptide-8 (or acetyl hexapeptide-3 or agireline), and these ingredients have been reported to have an additive synergy in significantly reducing wrinkles effect. Variations in this composition exist based on the different sequences of its compounds. Pentapeptide-18, its raw material form is a white to pale yellow powder, but it is also available in the form of aqueous solution. There are dozens of different pentapeptides used in skin care products. It helps visibly lighten dark spots and other forms of uneven tone.

Name: Pentapeptide 18 / leuphasyl

Type:Anti wrinkle peptide

CAS No.: 64963-01-5

Purity: ≥ 98%

Molecular weight: 569.7g/mol

Molecular formula: C29H39N5O7

Appearance: white powder or liquid

Storage condition: 2-8

Packing specification (powder): 1g, 10g, 100g packing specification (liquid): 20ml / bottle, 1kg / bottle

Application: cosmetic raw materials

1. Peptides in the form of lyophilized powder provided can be stably transported under normal temperature through sealed packaging.Peptides requiring long-term preservation shall be stored in a sealed container containing desiccant in the form of lyophilized powder and stored at a temperature below - 20 centigrade, which can avoid peptide degradation, bacterial degradation and oxidation, and the formation of secondary structure of peptide.

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