Decapeptide-12 | Skin whitening Peptide | Omizzur

Melanin cells are distributed among the cells in the basal layer of human epidermis. The tyrosinase contained in melanin cells can oxidize tyrosine to polysaccharide, and then through a series of metabolic processes, melanin can be produced finally. The more melanin is produced, the darker the skin is; On the contrary, the fairer the skin.

Tyrosinase has a unique dual catalytic function. It is the key enzyme of melanin synthesis in organism and is closely related to human aging. Its abnormal overexpression can lead to human pigmentation diseases. Tyrosinase inhibitors can treat the common pigmented skin diseases such as freckles, chloasma and senile plaques. Arbutin, vitamin C derivatives, kojic acid and its derivatives, green tea extract, licorice extract and other extracts in popular whitening cosmetics on the market are tyrosinase inhibitors, which mainly inhibit the synthesis of melanin by inhibiting the activity of tyrosinase, and then play the role of whitening.

Lumixyl decapeptide-12 can inhibit the synthesis of tyrosinase, thus effectively (40%) reducing the production of melanin. To maximize the desalination of excessive pigment deposition due to melasma, freckles, age spots, sunburn, uneven skin color and light damage. And lumixyl decapeptide-12 has no other whitening ingredients such as hydroquinone toxicity and side effects such as allergy, irritation and redness.

Decapeptide-12 Principle

Decapeptide-12 is a new type of oligopeptide. Its peptide sequence contains 2 tyrosines, 2 arginines and 3 serines. These carbohydrates have a strong effect on the activity of tyrosinase. inhibition. Therefore, decapeptide-12 can inhibit the activity of tyrosinase, thereby reasonably reducing the production of melanin. According to scientific research by AnanAbuUbeid and others, compared with hydroquinone, decapeptide-12 has a stronger ability to inhibit tyrosinase in human cells and is not toxic.

Basil et al. conducted a comparative test of decapeptide-12 in the treatment of chloasma on 5 volunteers using a half-face method, showing that the chloasma of 5 volunteers was significantly improved. The study by Kassim et al. showed that compared with patients who failed to receive 6 months of treatment with hydroquinone-tretinoin-steroid cream, half of the facial melasma treated with decapeptide-12 improved by more than 50%. .

Scientific research by experts and scholars has shown that decapeptide-12 is not easy to cause allergic or irritant allergic dermatitis, and it rarely occurs slight erythema, dryness and itching. Some experts believe that decapeptide-12 rarely causes erythema and itching, and will not cause post-inflammatory pigmentation. It is safe for long-term daily use and can be used as a substitute for other whitening agents. In the process of pigmentation treatment, it can be supplemented with hydroquinone products to reduce the risk of hyperquinone-related hyperpigmentation rebound and causing extrinsic melasma.

Decapeptide-12 Application

Decapeptide-12 powder is used as a product, which can be added in the final stage of cosmetics production, or mixed with skin care products after dissolving and applied. It is easy to operate and has a high safety factor. It is often used in skin brightening cream, skin beautifying liquid foundation, powder cake, and freckle cream (sunburn, chloasma).

Decapeptide-12 Analysis Data

Purity: > 98%

CAS:137665-91-9

Packing: 1 g(plastic bottle) or as you requirement

Character: white powder

Recommended dosage: 0.007% - 0.014%

Efficacy: whitening and freckle removing

MF:C66H91N17O17

MW:1395.52

Decapeptide-12 is a skin brightening treatment that is a safer alternative to hydroquinone and kojic acid that can help your skin regain a brighter and more even tone. It can be combined with other ingredients like vitamin C, niacinamide, and hyaluronic acid to enhance its whitening effects.

Decapeptide-12 is stable and does not readily degrade when exposed to light, heat or other environmental factors. The optimal molecular weight for skin penetration is said to be around 500 Daltons, and the optimal molecular weight for Decapeptide-12 is 1,395 Daltons. To solve the problem of penetration without PEG and other problematic penetration enhancing ingredients, we encapsulated this peptide in liposomes.

1. Peptides in the form of lyophilized powder provided can be stably transported under normal temperature through sealed packaging.Peptides requiring long-term preservation shall be stored in a sealed container containing desiccant in the form of lyophilized powder and stored at a temperature below - 20 centigrade, which can avoid peptide degradation, bacterial degradation and oxidation, and the formation of secondary structure of peptide.

2. Shipping: Deliver to worldwide by Fedex / DHL （Free shipping for orders over a certain amount）

3. Provide with the goods: quality analysis report (COA,MS,HPLC) ,Other corresponding analysis reports.

1. Peptide products include but are not limited to the above varieties,contact us by customer services: [email protected]

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