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Diabetes is a metabolic disorder characterized by long-term hyperglycemia, which is one of the most common chronic diseases in the world. The global diabetes data released by the International diabetes Alliance in 2019 shows that there are about 700 million adult diabetes patients (20-79 years old) in the world, and one person in every 11 adults has diabetes (463 million). The countries with the largest number of adult diabetes patients are China, India and the United States, of which the number of adult diabetes patients in China is up to 116 million.

In 2019, Novo Nordisk's oral Semaglutide , the first oral GLP-1 receptor agonist (GLP-1RA), was approved by the FDA for marketing. Oral administration can reduce the trauma of drug administration for diabetic patients, greatly improve drug compliance and convenience, and is expected to change the market pattern of diabetes drugs.

GLP-1 Receptor and GLP-1 Receptor Agonist

Glucagon like Peptide 1 (GLP-1) is a peptide hormone composed of thirty amino acids, encoded by the human glucagon gene, and secreted by intestinal L cells.

Development of Semaglutide Injection Formulation

Semaglutide , developed by Novo Nordisk, was initially designed as a powerful and lasting subcutaneous injection anti diabetes drug, with the frequency of once a week to improve convenience. Somaglutide was approved by the FDA for marketing in December 2017, and is the seventh globally approved GLP-1RA, following exenatide, Liraglutide, Abiglutide, Dulaglutide, Lisenside, and Benarutide.

As Novo Nordisk's second GLP-1RA drug, Semaglutide 's research and development strategy draws on the company's first GLP-1RA drug, Liraglutide, to modify the sequence structure of endogenous GLP-1 and extend the plasma half-life by modifying the fatty acid side chains on the peptide chain skeleton to bind to human albumin.

Molecular Structure Diagram of Semaglutide Peptide:

About Omizzur Biotech & Semaglutide Synthesis

Omizzur synthesizes high-purity Semaglutide API and related impurities for scientific research use, the product does not directly affect the human body. For semaglutide peptide powder buy please contact Omizzur customer service team for details.

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Storage condition: 2-8 ° C

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