Boc-His(Trt)-Aib-OH CAS 2061897-68-3 | Semeglutide Side Chain Supply

Boc-His(Trt)-Aib-OH is a small molecule peptide composed of two amino acids, used for the synthesis of semaglutide. Boc-His(Trt)-Aib-OH is used under the Boc strategy in peptide liquid-phase synthesis reactions.

The side chain of Semaglutide: Boc-His(Trt)-Aib-OH, which is the raw material of semaglutide, is a key component in the synthesis of the hypoglycemic drug semaglutide. Boc-His(Trt)-Aib-OH, as an important pharmaceutical intermediate, plays a crucial role in the synthesis of hypoglycemic drugs such as semaglutide. Its unique chemical structure and excellent physical properties make this compound have broad application prospects in drug development and production

The side chain of semaglutide contains multiple functional groups, including tert butoxide (tBuO), carboxyl (COOH), amino (NH2), and AEEA (2- [2- (Fmoc amino) ethoxy] ethoxyacetic acid) units. The presence of these functional groups endows the compound with high activity and selectivity in chemical reactions, making it suitable for various synthetic pathways.

Semaglutide & Impurities

Semaglutide is a long-acting glucagon like peptide-1 (GLP-1) analog used for the treatment of type II diabetes mellitus (T2DM). Based on the natural human GLP-1 molecule, it has been modified to retain up to 94% of the amino acid sequence homology of GLP-1, and has significantly extended the half-life in vivo. Once administered weekly, it can effectively reduce blood sugar.

Up to now, the efficacy of semaglutide discovered in numerous studies has included various effects such as lowering blood sugar, weight control, lowering blood pressure and fat, and protecting the cardiovascular system.

The impurities of semaglutide include oxides, ketones, polymers, etc., which may affect the stability and safety of semaglutide. Therefore, it is necessary to qualitatively and quantitatively analyze the relevant impurities, reduce impurity interference, improve synthesis and purification efficiency, and further ensure the quality and safety of semaglutide.

Popular Semaglutide Fragments | Omizzur

Omizzur Biotech

Omizzur is mainly engaged in the production of fmoc/boc amino acid derivatives, peptide APIs and peptide impurities, reference standards and chemical reference standards, focusing on the synthesis of amino acid derivatives and peptides. 

Omizzur contributes to the research and development of various peptides and generic such as semaglutide.

Boc-His(Trt)-Aib-OH In Stock

Storage:-20°C, Inert atmosphere

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