Methods of Peptide Synthesis

Methods for peptide synthesis are mainly divided into two categories: chemical and biological methods.

1. Chemical method

The chemical method is to gradually react small molecule amino acids to synthesize peptides. Among them, Fmoc and Boc are the more common synthesis methods.

The Fmoc solid-phase synthesis method refers to using fluoroformate (Fmoc) as the protecting group for the N-terminus of amino acids, and adding amino acids to the peptide chain sequentially through a series reaction. Then, through a series of steps, the peptide is synthesized.

The Boc method uses tert-butoxycarbonyl (Boc) as the protecting group for the N-terminus of the amino acid. The amino acids are also added to the peptide chain one by one through a series reaction, and then the synthesis is completed through a series of steps such as deprotection.

Today we will introduce the 10 most famous best peptide synthesis companies specializing in chemical synthesis methods. They perform well in their respective fields and can provide technical support to scientific research companies. There are some companies that you may be familiar with. We will start introducing them below.

Bachem is the leader in the peptide industry, headquartered in Switzerland, with branches in the United States and Japan. Bachem has a history of over 50 years. If you need high-quality peptides and don't know how to choose a company, you'll have a no-brainer in choosing Bachem: it's trustworthy.

>> web: www.bachem.com

GenScript is an important global supplier of gene synthesis, peptide synthesis, and antibodies. It was founded in 2002 and is headquartered in the United States, with a market share of approximately 30%. GenScript's services and products have been cited in more than 85,100 academic journal documents worldwide.

>> web: www.genscript.com

Thermo Fisher Scientific Inc is the world leader in serving science, with annual revenue of over $40 billion. This is a comprehensive biological company whose main strengths are concentrated in the fields of antibodies, cell research, and genes.

>> web: www.thermofisher.com

MilliporeSigma is also a comprehensive and established biological company. With more than 28,000 employees, it is also trustworthy. It specializes in customized products and has branches in more than 50 countries around the world.

>>web: www.sigmaaldrich.com

PolyPeptide is a manufacturer specializing in peptide API synthesis, specializing in CDMP services for peptide- and oligonucleotide-based therapies, with operations in Europe, the United States and India. Headquartered in Switzerland. A very professional peptide company.

>>web: www.polypeptide.com

Peptide Institute, Inc is a Japanese biological company, mainly engaged in Peptide Synthesis and Carbohydrate Synthesis. It is famous for its rigorous work attitude.

>> web: www.peptide.co.jp/en/

AmbioPharm, a global peptide CDMO, was founded in 2005 and is headquartered in USA, specializing in developing peptide-based APIs at small to large scales. It has peptide GMP manufacturing capabilities.

>>web: www.ambiopharm.com

Based in the UK, Biosynth Ltd specializes in the biologically active peptides, antibodies, proteins, enzymes and reagents for Life Science Research. Biosynth also excels in peptides, from discovery and optimization and libraries and GMP NCEs and neoantigens.

>> web: www.biosynth.com

LifeTein, was founded in 2008, USA. Their custom services include peptide synthesis and conjugation, as well as custom protein, antibody, and chemical services.

>> web: www.lifetein.com

---

Omizzur is a biological company from China. It is a young peptide synthesis company founded in 2018. Its main advantages are customized peptides, peptide impurities, amino acid derivatives, etc. Compared with the previous companies, Omizzur products are cheaper and also provide complete peptide detection reports and certificates.

>>web: www.omizzur.com